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BOVINE COLOSTRUM & TISSUE REPAIR/WOUND HEALING

BOVINE COLOSTRUM TISSUE REPAIR

Bovine Colostrum & Tissue Repair/Wound Healing

Jogi R, Tager MJ, Perez D, Tsapekos M. Bovine Colostrum, Telomeres, and Skin Aging. J Drugs Dermatol. 2021 May 1;20(5):538-545. When liposomal bovine colostrum was applied to human fibroblasts (skin cells) in vitro, it had a protective effect on the telomere length. Instead of the telomeres shortening under the oxidative stress, their length was maintained. These results suggest that topical treatment of liposomal bovine colostrum (Colostrum-LD®) could enhance skin health as the skin ages.
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Kovacs D, Maresca V, Flori E, Mastrofrancesco A, Picardo M, Cardinali G. Bovine colostrum induces the differentiation of human primary keratinocytes. FASEB J. 2020 May;34(5):6302-6321. Bovine colostrum was applied to human keratinocytes (skin cells) and showed a potential benefit for the treatment of skin diseases that are related to perturbed barrier function (“leaky skin”).
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Kshirsagar AY, Vekariya MA, Gupta V, Pednekar AS, Mahna A, Patankar R, Shaikh A, Nagur B. A comparative study of colostrum dressing versus conventional dressing in deep wounds. Journal of Clinical and Diagnostic Research. 2015 Apr;9(4):PC01-4. Colostrum powder dressings are safe, promoters of wound healing, and have more patient compliance in terms of less pain, and fewer number of dressings required.
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Kovacs D, Cardinali G, Aspite N, Picardo M. Bovine colostrum promotes growth and migration of the human keratinocyte HaCaT cell line. Growth Factors. 2009 Dec;27(6):448-55. The biological activities of colostrum are specifically mediated by the growth factor-induced activation of tyrosine kinase receptors and underline the relevance of the synergistic action exerted by the growth factors in stimulating keratinocyte proliferation and migration essential for tissue repair.
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Torre C, Jeusette I, Serra M, Brazis P, Puigdemont A. Bovine colostrum increases proliferation of canine skin fibroblasts. J Nutr. 2006 Jul;136(7 Suppl):2058S-2060S. Freeze-dried skim bovine colostrum maintains activity of the bioactive substances that promote the cellular growth, suggesting potential proliferative actions by direct contact with target cells.
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