Now Loading

BOVINE COLOSTRUM & IMMUNE RESPONSE, ALLERGIES & INFECTIONS

BOVINE COLOSTRUM IMMUNE RESPONSE

Bovine Colostrum & Immune Response, Allergies & Infections

Sangild PT, Vonderohe C, Melendez Hebib V, Burrin DG. Potential Benefits of Bovine Colostrum in Pediatric Nutrition and Health. Nutrients. 2021 Jul 26;13(8):2551. This review study examines bovine colostrum supplementation and improved health outcomes related to immature immune and gut functions. Conditions affecting infants and children, including diarrhea, infection, growth-failure, preterm birth, necrotizing enterocolitis, short-bowel syndrome, and mucositis may benefit from adding bovine colostrum to the diet, although not exclusive BD feeding is not recommended.
ABSTRACT | FULL TEXT

Ameli F, Ciprandi G. Sinerga may prevent recurrent respiratory infections in allergic children. J Biol Regul Homeost Agents. 2019 Mar-Apr;33(2):601-607. A dietary supplement containing bovine colostrum was tested in allergic children with recurrent respiratory infections and shown to significantly prevent respiratory infections and reduce events depending on allergic inflammation.
ABSTRACT

Ulfman LH, Leusen JHW, Savelkoul HFJ, Warner JO, van Neerven RJJ. Effects of Bovine Immunoglobulins on Immune Function, Allergy, and Infection. Front Nutr. 2018 Jun 22;5:52. Bovine IgG derived from colostrum and milk, from either vaccinated or non-vaccinated cows are shown to be effective in binding to human pathogens and allergens, neutralizing experimental infection of human cells, and limiting gastrointestinal inflammation. As these mechanisms become more established and can explain why bovine IgG can have immunological effects in vivo, including bovine immunoglobulins in specialized dairy products and infant nutrition may be a promising approach to support immune function in vulnerable groups such as infants, children, elderly and immunocompromised patients.
ABSTRACT | FULL TEXT

Saad K, Abo-Elela MG, El-Baseer KA, Ahmed AE, Ahmad FA, Tawfeek MS, El-Houfey AA, AboulKhair MD, Abdel-Salam AM, Abo-Elgheit A, Qubaisy H, Ali AM, Abdel-Mawgoud E. Effects of bovine colostrum on recurrent respiratory tract infections and diarrhea in children. Medicine (Baltimore). 2016 Sep;95(37):e4560. Bovine colostrum is effective in the prophylaxis of recurrent upper respiratory tract infections and diarrhea as it reduces the number of episodes and the hospitalization due to these infections. Results suggest that bovine colostrum could be utilized as a therapeutic option for children with recurrent URTI and diarrhea.
ABSTRACT | FULL TEXT

Yadav R, Angolkar T, Kaur G, Buttar HS. Antibacterial and Antiinflammatory Properties of Bovine Colostrum. Recent Pat Inflamm Allergy Drug Discov. 2016;10(1):49-53. Bovine colostrum showed significant antimicrobial activity against Escherichia. coli, Staphylococcus. aureus, Proteus. vulgaris, Enterobacter. aerogenes and Salmonella. typhi.
ABSTRACT

Jones AW, March DS, Curtis F, Bridle C. Bovine colostrum supplementation and upper respiratory symptoms during exercise training: a systematic review and meta-analysis of randomised controlled trials. BMC Sports Sci Med Rehabil. 2016 Jul 26;8:21. This review showed that bovine colostrum supplementation may be effective in preventing the incidence of upper respiratory symptoms (days and episodes) in adults engaged in exercise training

ABSTRACT | FULL TEXT

Sponseller JK, Steele JA, Schmidt DJ, Kim HB, Beamer G, Sun X, Tzipori S. Hyperimmune bovine colostrum as a novel therapy to combat Clostridium difficile infection. J Infect Dis. 2015 Apr 15;211(8):1334-41. Nonimmune colostrum-treated piglets developed moderate to severe diarrhea and colitis. In contrast, (HBC) hyperimmune bovine colostrum-treated piglets had mild or no diarrhea and mild or no colitis. HBC provides an oral, cost-effective, and safe alternative to antibiotic therapy for clostridium difficile. By preserving intestinal microbiota, HBC may be more efficacious than antibiotics.
ABSTRACT | FULL TEXT

Wong EB, Mallet JF, Duarte J, Matar C, Ritz BW. Bovine colostrum enhances natural killer cell activity and immune response in a mouse model of influenza infection and mediates intestinal immunity through toll-like receptors 2 and 4. Nutr Res. 2014 Apr;34(4):318-25. Colostrum-supplemented mice demonstrated less reduction in body weight after influenza infection, indicating a less severe infection, increased NK cell cytotoxicity, and less virus burden in the lungs compared with controls. Colostrum supplementation enhanced NK cell cytotoxicity and improved the immune response to primary influenza virus infection in mice.
ABSTRACT

Steele J, Sponseller J, Schmidt D, Cohen O, Tzipori S. Hyperimmune bovine colostrum for treatment of GI infections: A review and update on Clostridium difficile. Hum Vaccin Immunother. 2013 Jul;9(7):1565-8. Hyperimmune bovine colostrum was efficacious in the treatment of C. difficile infection in the gnotobiotic piglet model, and may provide an effective treatment alternative to antibiotics, which can spare the normal gut microflora, and reduce rates of recurrence and antibiotic resistance.
ABSTRACT | FULL TEXT

Orth K, Knoefel WT, van Griensven M, Matuschek C, Peiper M, Schrumpf H, Gerber PA, Budach W, Bölke E, Buhren BA, Schauer M. Preventively enteral application of immunoglobulin enriched colostrums milk can modulate postoperative inflammatory response. Eur J Med Res. 2013 Nov 23;18:50. Prophylactic oral colostrum is likely to stabilize the gut barrier i.e. reduces the influx of lipopolysaccharides arising from Gram-negative bacteria and inhibits enterogenic endotoxemia. This appears to be a major mechanism underlying the therapeutic effect in patients at risk for Gram-negative septic shock.
ABSTRACT | FULL TEXT

Adar T, Ben Ya’acov A, Lalazar G, Lichtenstein Y, Nahman D, Mizrahi M, Wong V, Muller B, Rawlin G, Ilan Y. Oral administration of immunoglobulin G-enhanced colostrum alleviates insulin resistance and liver injury and is associated with alterations in natural killer T cells. Clin Exp Immunol. 2012 Feb;167(2):252-60. Oral administration of hyperimmune colostrums decreased alanine aminotransferase (ALT) serum levels and serum triglycerides and glucose intolerance was improved compared to controls. These results were accompanied by a decrease in serum tumor necrosis factor (TNF)-α levels and an increase in the number of splenic NKT cells. These data suggest that oral administration of hyperimmune colostrum preparations can alleviate chronic inflammation, liver injury and insulin resistance associated with NASH.
ABSTRACT | FULL TEXT

Kaducu FO, Okia SA, Upenytho G, Elfstrand L, Florén CH. Effect of bovine colostrum-based food supplement in the treatment of HIV-associated diarrhea in Northern Uganda: a randomized controlled trial. Indian J Gastroenterol. 2011 Dec;30(6):270-6. The addition of a bovine colostrum-based supplement to standard anti-diarrhea therapy is effective in treatment of HIV-associated diarrhea.
ABSTRACT

Elfstrand L, Florén CH. Management of chronic diarrhea in HIV-infected patients: current treatment options, challenges and future directions. HIV/AIDS (Auck) 2010;2:219-24. Bovine colostrum-based food can be useful for managing chronic diarrhea in HIV-infected patients, enhancing both nutritional and immunological status.
ABSTRACT | FULL TEXT

Belcaro G, Cesarone MR, Cornelli U, Pellegini L, Ledda A, Grossi MG, Dugall M, Ruffini I, Fano F, Ricci A, Stuard S, Luzzi R, Grossi MG, Hosoi M. Prevention of flu episodes with colostrum and Bifivir compared with vaccination: an epidemiological, registry study. Panminerva Med. 2010;52(4):269-75. The number of influenza episodes registered with the immunnomodulators was significantly lower than those observed in patients using vaccination or no prevention. The number of days of disease was higher in untreated controls compared to the groups treated with immunomodulators and 2 times higher in the vaccination group compared to the same groups.
ABSTRACT

Rawal P, Gupta V, Thapa BR. Role of colostrum in gastrointestinal infections. Indian J Pediatr. 2008 Sep;75(9):917-21. Colostrum has been found to be effective in infantile hemorrhagic diarrheas, other diarrheas and reduces the likelihood of disease progressing to hemolytic uremic syndrome. It has also been tested in H. pylori infection and diarrhea in immunodeficiency.
ABSTRACT

Boldogh I, Aguilera-Aguirre L, Bacsi A, Choudhury BK, Saavedra-Molina A, Kruzel M. Colostrinin decreases hypersensitivity and allergic responses to common allergens. Int Arch Allergy Immunol. 2008;146(4):298-306. Colostrinin (mixture of low-molecular-weight, proline-rich polypeptides in colostrum) decreased IgE/IgG1 production, airway eosinophilia, mucin production and hypersensitivity induced by allergenic extracts from ragweed pollen grains and house dust mites.
ABSTRACT

Vilte DA, Larzábal M, Cataldi AA, Mercado EC. Bovine colostrum contains immunoglobulin G antibodies against intimin, EspA, and EspB and inhibits hemolytic activity mediated by the type three secretion system of attaching and effacing Escherichia coli. Clin Vaccine Immunol. 2008 Aug;15(8):1208-13. Early colostrum from cows contains antibodies, lactoferrin, and other unidentified substances that impair type three secretion system (TTSS) function in attaching and effacing E. coli strains. Bovine colostrum might act by reducing Enterohemorrhagic Escherichia coli (EHEC) colonization in newborn calves and could be used as a prophylactic measure to protect non-breast-fed children against EHEC infection in an area of endemicity.
ABSTRACT | FULL TEXT

Hammarström L, Weiner CK. Targeted antibodies in dairy-based products. Adv Exp Med Biol. 2008;606:321-43. Bovine colostrum-based immune milk products have proven efficacy in prophylaxis and treatment against various infectious diseases in humans such as diarrheal diseases caused by various pathogens like E. coli and rotavirus.
ABSTRACT

Cesarone MR, Belcaro G, Di Renzo A, Dugall M, Cacchio M, Ruffini I, Pellegrini L, Del Boccio G, Fano F, Ledda A, Bottari A, Ricci A, Stuard S, Vinciguerra G. Prevention of influenza episodes with colostrum compared with vaccination in healthy and high-risk cardiovascular subjects: the epidemiologic study in San Valentino. Clin Appl Thromb Hemost. 2007;13(2):130-6. The incidence of complications and hospital admission from influenza was higher in the group that received only a vaccination compared with the colostrum groups. Colostrum, both in healthy subjects and high-risk cardiovascular patients, is at least 3 times more effective than vaccination to prevent flu and is very cost-effective.
ABSTRACT | FULL ARTICLE

Florén CH, Chinenye S, Elfstrand L, Hagman C, Ihse I. ColoPlus, a new product based on bovine colostrum, alleviates HIV-associated diarrhea. Scand J Gastroenterol. 2006 Jun;41(6):682-6. Patients with HIV-associated diarrhea experienced decrease in stool evacuations per day from 7.0+/-2.7 to 1.3+/-0.5, a substantial decrease in self-estimated fatigue of 81%, an increase in body-weight of 7.3 kg per patient and an increase in CD4+ count by 125% after taking a bovine colostrum supplement for four weeks.
ABSTRACT

Jensen GS, Patel D, Benson KF. A novel extract from bovine colostrum whey supports innate immune functions. II. Rapid changes in cellular immune function in humans. Prev Med. 2012 May;54 Suppl:S124-9. Bovine colostrum low-molecular weight fraction (CLMWF) increased phagocytic activity and rapid transient changes in NK cell numbers. Data suggest that upon consumption, interaction of CLMWF with immune cells in the gut mucosa triggers immediate events with systemic consequences.
ABSTRACT

Benson KF, Carter SG, Patterson KM, Patel D, Jensen GS. A novel extract from bovine colostrum whey supports anti-bacterial and anti-viral innate immune functions in vitro and in vivo: I. Enhanced immune activity in vitro translates to improved microbial clearance in animal infection models. Prev Med. 2012 May;54 Suppl:S116-23. Bovine colostrum low-molecular weight fraction (CLMWF) consumed acutely during bacterial (Streptococcus) and viral (Influenza) infections in vivo reduced bacterial and viral loads in the lungs within 24 hours. Viral load was also reduced when CLMWF was introduced intranasally. Data suggest that the support of antimicrobial immune defense mechanisms and maturation of antigen-presenting cells in vitro translates to protection in vivo when CLMWF is introduced across mucosal membranes.
ABSTRACT

Lilius EM, Marnila P. The role of colostral antibodies in prevention of microbial infections. Curr Opin Infect Dis. 2001 Jun;14(3):295-300. Colostrum offers passive protection against a variety of microbial pathogens in the form of specific immunoglobulin A, G and M antibodies. It is especially effective in the prevention of various gastroenteric infections.
ABSTRACT

Rump JA, Arndt R, Arnold A, Bendick C, Dichtelmüller H, Franke M, Helm EB, Jäger H, Kampmann B, Kolb P, et al. Treatment of diarrhoea in human immunodeficiency virus-infected patients with immunoglobulins from bovine colostrum. Clin Investig. 1992 Jul;70(7):588-94. Immunoglobulins from bovine colostrum were very effective in treating chronic diarrhea in AIDS patients from a variety of causes. Colostral immunoglobulins are highly resistant to digestion in the gastrointestinal tract.
ABSTRACT