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BOVINE COLOSTRUM & G.I. HEALTH/INTESTINAL HYPERPERMEABILITY (“Leaky Gut”)

BOVINE COLOSTRUM GI HEALTH

Bovine Colostrum & G.I. Health/Intestinal Hyperpermeability (“Leaky Gut”)

Playford RJ, Weiser MJ. Bovine Colostrum: Its Constituents and Uses. Nutrients. 2021 Jan 18;13(1):265. This review article describes the main constituents, quality control and an overview of the use of bovine colostrum in health and disease, including intestinal hyperpermeability.
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Playford RJ, Choudhry N, Kelly P, Marchbank T. Effects of Bovine Colostrum with or without Egg on In Vitro Bacterial-Induced Intestinal Damage with Relevance for SIBO and Infectious Diarrhea. Nutrients. 2021 Mar 22;13(3):1024.  Bovine colostrum plus egg strengthens gut mucosal integrity against a battery of bacteria relevant for SIBO and for infectious diarrhea. Such a preparation may provide clinical value for these conditions, especially SIBO where bacterial eradication may be difficult to achieve.
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Guberti M, Botti S, Capuzzo MT, Nardozi S, Fusco A, Cera A, Dugo L, Piredda M, De Marinis MG. Bovine Colostrum Applications in Sick and Healthy People: A Systematic Review. Nutrients. 2021 Jun 25;13(7):2194. Among the many purported uses of bovine colostrum, this review article details the benefit of reducing intestinal permeability in both sick and healthy adults.
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Playford RJ, Garbowsky M, Marchbank T. Pasteurized Chicken Egg Powder Stimulates Proliferation and Migration of AGS, RIE1, and Caco-2 Cells and Reduces NSAID-Induced Injury in Mice and Colitis in Rats. J Nutr. 2020 Jun 1;150(6):1434-1442. Chicken eggs and bovine colostrum contain proteins with antimicrobial, immunoregulatory, and growth factor activity. When egg powder and colostrum were added together, results were enhanced, suggesting such a preparation could be used for the  prevention and treatment of gut injuries.
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Hałasa M, Maciejewska-Markiewicz D, Baśkiewicz-Hałasa M, Safranow K, Stachowska E. Post-Delivery Milking Delay Influence on the Effect of Oral Supplementation with Bovine Colostrum as Measured with Intestinal Permeability Test. Medicina (Kaunas). 2020 Sep 24;56(10):495. The ability of bovine colostrum (as a nutritional supplement) helps regulate intestinal homeostasis (permeability) decreases beyond the first few days of lactation. As measured by the lactulose/mannitol (L/M) test for intestinal permeability, this study suggests that first milking colostrum is more effective than subsequent milkings.
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Eslamian G, Ardehali SH, Baghestani AR, Vahdat Shariatpanahi Z. Effects of early enteral bovine colostrum supplementation on intestinal permeability in critically ill patients: A randomized, double-blind, placebo-controlled study. Nutrition. 2019 Apr;60:106-111. Early enteral bovine colostrum supplementation in intensive care unit-hospitalized patients was investigated for its effect on intestinal permeability and endotoxin concentration. Both parameters decreased significantly compared to ICU patients who did not receive bovine colostrum supplementation.

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March DS, Jones AW, Thatcher R, Davison G. The effect of bovine colostrum supplementation on intestinal injury and circulating intestinal bacterial DNA following exercise in the heat. Eur J Nutr. 2018 Mar 24. Fourteen days of bovine colostrum supplementation was effective at reducing intestinal injury following exercise in the heat, but exercise responses (temporal pattern) of bacterial DNA were not influenced by colostrum, although overall levels may be lower.
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Hałasa M, Maciejewska D, Baśkiewicz-Hałasa M, Machaliński B, Safranow K, Stachowska E. Oral supplementation with bovine colostrum decreases intestinal permeability and stool concentrations of zonulin in athletes. Nutrients. 2017 Apr 8;9(4):370. Bovine colostrum supplementation was safe and effective in decreasing of intestinal permeability in athletes at increased risk of elevated permeability caused by strenuous physical activity.
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March DS, Marchbank T, Playford RJ, Jones AW, Thatcher R, Davison G. Intestinal fatty acid-binding protein and gut permeability responses to exercise. Eur J Appl Physiol. 2017 May;117(5):931-941. Fourteen days of oral bovine colostrum supplementation (20 grams/day) blunted the normal increase in intestinal permeability (as measured by urinary lactulose/rhamnose ratio), following strenuous exercise.
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Davison G, Marchbank T, March DS, Thatcher R, Playford RJ. Zinc carnosine works with bovine colostrum in truncating heavy exercise-induced increase in gut permeability in healthy volunteers. Am J Clin Nutr. 2016 Aug;104(2):526-36. Zinc carnosine (ZnC), taken alone or with bovine colostrum, increased epithelial resistance and the tight junction structure. Supplementation has potential value in mediating increased gut permeability for athletes and in the prevention of heat stroke in military personnel.
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Blais M, Pouliot Y, Gauthier S, Boutin Y, Lessard M. A gene expression programme induced by bovine colostrum whey promotes growth and wound-healing processes in intestinal epithelial cells. J Nutr Sci. 2014 Nov 13;3:e57. Colostrum specific bioactive content could be beneficial for intestinal epithelial cell homoeostasis by controlling biological processes implicated in wound healing through a precise gene expression programme.
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Marchbank T, Davison G, Oakes JR, Ghatei MA, Patterson M, Moyer MP, Playford RJ. The nutriceutical bovine colostrum truncates the increase in gut permeability caused by heavy exercise in athletes. Am J Physiol Gastrointest Liver Physiol. 2011 Mar;300(3):G477-84. Bovine colostrum may have value in enhancing athletic performance and preventing heat stroke by halting the normal increase in gut permeability.
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Kim JW, Jeon WK, Yun JW, Park DI, Cho YK, Sung IK, Sohn CI, Kim BI, Yeom JS, Park HS, Kim EJ, Shin MS. Protective effects of bovine colostrum on non-steroidal anti-inflammatory drug induced intestinal damage in rats. Asia Pac J Clin Nutr. 2005;14(1):103-7. Administration of bovine colostrum reduced the increase in intestinal permeability, enteric bacterial overgrowth, protein losing enteropathy and mucosal villous damage of the small intestine induced by diclofenac. Bovine colostrum may have a beneficial effect in prevention of NSAID induced small intestinal injuries.
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Prosser C, Stelwagen K, Cummins R, Guerin P, Gill N, Milne C. Reduction in heat-induced gastrointestinal hyperpermeability in rats by bovine colostrum and goat milk powders. J Appl Physiol (1985). 2004 Feb;96(2):650-4. Bovine colostrum powder can partially alleviate the effects of hyperthermia on gastrointestinal permeability in the intact animal. The protective effect may involve modulation of tight junction permeability.
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Khan Z, Macdonald C, Wicks AC, Holt MP, Floyd D, Ghosh S, Wright NA, Playford RJ. Use of the ‘nutriceutical’, bovine colostrum, for the treatment of distal colitis: results from an initial study. Aliment Pharmacol Ther. 2002 Nov;16(11):1917-22. Bovine colostrum enema shows potential as a novel therapy for left-sided colitis with additional benefits over using mesalazine alone.
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Playford RJ, MacDonald CE, Calnan DP, Floyd DN, Podas T, Johnson W, Wicks AC, Bashir O, Marchbank T. Co-administration of the health food supplement, bovine colostrum, reduces the acute non-steroidal anti-inflammatory drug-induced increase in intestinal permeability. Clin Sci (Lond). 2001 Jun;100(6):627-33. This study showed that colostrum also prevents an increase in gastrointestinal permeability due to NSAID use, whereas NSAID use alone without colostrum causes an increase in permeability.
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Playford RJ, Macdonald CE, Johnson WS. Colostrum and milk-derived peptide growth factors for the treatment of gastrointestinal disorders. Am J Clin Nutr. 2000 Jul;72(1):5-14. A review article of the research examining the potential benefits of using recombinant peptides or colostral-derived preparations for a wide range of gastroenterological conditions. Early results are encouraging and authors envisage the standard use of these products in the clinical management of gastrointestinal diseases within the next decade.
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Playford RJ, Floyd DN, Macdonald CE, Calnan DP, Adenekan RO, Johnson W, Goodlad RA, Marchbank T. Bovine colostrum is a health food supplement which prevents NSAID induced gut damage. Gut 1999 May;44(5):653-8. Although non-steroidal anti-inflammatory drugs (NSAIDs) are very effective in controlling joint pain in arthritis, their use also causes significant, and sometimes fatal, gastrointestinal damage. Supplementation with colostrum, however, significantly reduced and healed injury caused by NSAIDs. TGF stimulates new cell growth and a 20% increase in intestinal villi height. By repairing the intestinal mucosal barrier and increasing the surface area in the gut, more nutrients may be absorbed into the bloodstream.
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